Home > Blossary: Addictive Drugs
A blossary of terms related to addictive drugs.

Category: Law

28 Terms

Created by: Silentchapel

Number of Blossarys: 95

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Pethidine is indicated for the treatment of moderate to severe pain, and is delivered as a hydrochloride salt in tablets, as a syrup, or by intramuscular, subcutaneous or intravenous injection. For much of the 20th century, pethidine was the opioid of choice for many physicians; in 1975 60% of doctors prescribed it for acute pain and 22% for chronic severe pain. Compared with morphine, pethidine was thought to be safer, carry a lower risk of addiction and to be superior in treating the pain associated with biliary spasm or renal colic due to its putative anticholinergic effects. It was later discovered that these were all myths and that it carried an at least equal risk of addiction, possessed no advantageous effects on biliary spasm or renal colic compared to other opioids and that, due to its toxic metabolite, norpethidine, it was more toxic than other opioids, especially during long-term use.

Domain: Law enforcement; Category: Drug trafficking

Pethidine yra skirtas gydyti vidutinio sunkumo ir sunkus skausmas, ir pristatomas kaip hidrochlorido druskos tabletės, kaip su sirupu, arba į raumenis, po oda ar į veną injekcijos. Didžiąją 20 a., pethidine buvo opioidų pasirinkimo daug gydytojų; 1975 metais 60 % gydytojų nustatyta ūmaus skausmo ir 22 % lėtinio didelio skausmo. Palyginti su morfinas, pethidine buvo manoma saugiau, mažesnė rizika priklausomybės ir bus pranašesnis gydant skausmo, susijusios su tulžies spazmai ar inkstų kolika dėl savo spėjamas anticholinerginis poveikis. Vėliau buvo aptikta, kad tai buvo visi mitai ir kad ji vykdoma ne mažiau kaip lygus rizika priklausomybės, turėjo joks naudingiausią poveikis tulžies spazmai ar inkstų kolika, palyginti su kitais opioidais ir kad dėl jo toksiškų metabolitų, norpethidine, jis buvo labiau toksiškas nei kiti opioidai, ypač ilgalaikio naudojimo metu.

Domain: Law enforcement; Category: Drug trafficking

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