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fluorine F 18 6-fluorodopamine
A radioconjugate consisting of 6-fluorodopamine labeled with fluorine F18 (6-(18F)FDA), with potential diagnostic activity. Upon administration, 6-(18F)FDA is taken up by presynaptic sympathetic nerve endings via the norepinephrine transporter (NET) uptake-1. Once inside, 6-(18F)FDA is rapidly converted by dopamine-beta-hydroxylase into 6-(18F)fluoronorepinephrine (6-(18F)FNE) and stored into neuronal storage vesicles. Upon positron emission tomographic (PET) scanning of the F18, sympathetic innervated regions can be visualized, such as those in pheochromocytoma.
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- Category: Cancer drugs
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