Genetic disorders

Genetic disorders

Genetic diseases, syndromes, or conditions caused by genetic variations and abnormalities in genes or chromosomes.

Industry: Health care

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Genetic disorders

colon

Health care; Genetic disorders

The longest part of the large intestine, which is a tube-like organ connected to the small intestine at one end and the anus at the other. The colon removes water and some nutrients and electrolytes ...

conformation-sensitive gel electrophoresis (CSGE)

Health care; Genetic disorders

A type of mutation scanning in which a segment of DNA is screened for mismatch pairing between normal and mutated base pairs.

denaturing gradient gel electrophoresis (DGGE)

Health care; Genetic disorders

Identification of mutations by electrophoresis of double-stranded DNA samples through a denaturing gradient, such as urea. Certain mutations affect the migration pattern by changing the point in the ...

lymphoid

Health care; Genetic disorders

Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.

loss of heterozygosity (LOH)

Health care; Genetic disorders

At a particular locus heterozygous for a deleterious mutant allele and a normal allele, a deletion or other mutational event within the normal allele renders the cell either hemizygous (one ...

microsatellite instability (MSI)

Health care; Genetic disorders

The presence of additional microsatellite alleles (repeated segments) in tumor cells, resulting from the inherent susceptibility of these areas to such alterations and from mutations in the DNA ...

transfer RNA (tRNA)

Health care; Genetic disorders

1) The small RNA molecules, 73-80 nucleotides long, that function during translation to align amino acids at the ribosomes in a sequence determined by the mRNA. There are about 30 different transfer ...