Agrippina is an opera seria in three acts by George Frideric Handel, from a libretto by Cardinal Vincenzo Grimani. Composed for the 1709–10 Venice Carnevale season, the opera tells the story of Agrippina, the mother of Nero, as she plots the downfall of the Roman Emperor Claudius and the installation of her son as emperor. Grimani's libretto, considered one of the best that Handel set, is an "anti-heroic satirical comedy", full of topical political allusions. Some analysts believe that it reflects the rivalry of Grimani with Pope Clement XI.

Handel composed Agrippina at the end of a three-year visit to Italy. It premiered in Venice at the Teatro San Giovanni Grisostomo on 26 December 1709, and was an immediate success. From its opening night it was given a then-unprecedented run of 27 consecutive performances, and received much critical acclaim. Observers were full of praise for the quality of the music—much of which, in keeping with the contemporary custom, had been borrowed and adapted from other works, including some from other composers. Despite the evident public enthusiasm for the work, Handel did not promote further stagings. There were occasional productions in the years following its premiere but, when Handel's operas fell out of fashion in the mid-18th century, it and his other dramatic works were generally forgotten.

In the 20th century, Handelian opera began a revival which, after productions in Germany, saw Agrippina premiered in Britain and in America. In recent years performances of the work have become more common, with innovative stagings at the New York City Opera and the London Coliseum in 2007. Modern critical opinion is that Agrippina is Handel's first operatic masterpiece, full of freshness and musical invention which have made it one of the most popular operas of the continuing Handel revival.