Molecular biology

Molecular biology

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Molecular biology

Stokes radius

Biology; Biochemistry

On the assumption that it is a sphere, the apparent radius of a macromolecule in solution, as determined from its hydrodynamic behavior, i.e. intrinsic viscosity, diffusion or sedimentation ...

homologue cloning

Biology; Biochemistry

A strategy for selection of polynucleotide sequences closely homologous to one that is known by its partial hybridization with a probe designed for the latter; e.g. a labelled probe that is ...

hydrophobic cluster analysis (HCA)

A method for comparison of amino acid sequences of proteins to detect regions of conformational similarity. Groups of neighboring hydrophobic amino acid residues are identified in a HCA plot that is ...

diffraction pattern

Biology; Biochemistry

The array of reflections obtained by crystallography. Each reflection indicates an intensity and, by its location, the angle with respect to the incident beam. Because a sharp pattern requires the ...

magnet-assisted subtractive technique (MAST)

Biology; Biochemistry

A method for detection of the tissue specificity of gene expression. Two tissues are compared: a deficient tissue from which single-stranded cDNA (driver cDNA) is prepared and attached to magnetic ...

ligase

Biology; Biochemistry

One of a class of enzymes that join two substrate molecules in energy- (usually ATP-) dependent reaction, e.g. an amino acyl-tRNA synthetase, a carboxylase; in molecular biology, an enzyme that ...

repertoire cloning

Biology; Biochemistry

A method to produce human monoclonal antibodies. mRNAs are isolated from a tissue that generates immunoglobulins (e.g. spleen) and a reverse transcriptase makes cDNA copies of them. The Fd regions, ...