Molecular biology

Molecular biology

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Molecular biology

competitive inhibition

Biology; Biochemistry

A form of enzyme inhibition in which the inhibitor competes with the substrate for the enzyme's substrate-binding site. The result is an increase in the K m value while leaving V max unaltered.

An RNA molecule that owing to peculiarities in its folding, is able to catalyze the interchange of some of its phosphodiester linkages to achieve intramolecular splicing. Examples of ribozyme groups ...

ribosome jumping

Biology; Biochemistry

5'-Cap-dependent initiation of translation of some viral mRNAs in which a ribosome subunit recognizes the 5'-cap of the mRNA but 'jumps' over the 5'-non-translated region of strong secondary ...

multi-wavelength anomalous diffraction (MAD)

Biology; Biochemistry

For proteins that contain a heavy metal, or synthesized with selenomethionine in place of methionine, an approach to solving their X-ray crystallography structure that takes advantage of the ...

knock-out

Biology; Biochemistry

An animal or plant from which a certain gene has been deliberately deleted, in order to observe, as a test for the gene's physiological significance, the viability or phenotype of the organism. A ...

inverse PCR

Biology; Biochemistry

A PCR protocol for amplification of sequences that flank a single known sequence. The source DNA is digested with a restriction endonuclease, circularized and ligated. Primers are constructed that ...

contig map

Biology; Biochemistry

A characterization of a chromosome or large portion of one by contiguous sequences, which are zones of overlap of partially characterized segments; especially used as a strategy for co-ordination of ...