Molecular biology

Molecular biology

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Molecular biology

surface-enhanced laser desorption/ionization (SELDI)

Biology; Biochemistry

A pre-mass spectroscopy screening and selection technique. Spots on an inert surface are modified to bind a desired types of protein; e.g. with phenyl or amino groups for hydrophobic or acidic ...

An enzymic activity associated with the cytoplasmic domain of several growth factor receptors. Two such molecules, when liganded to an effector molecule by their extracellular domains, phosphorylate ...

tetrad

Biology; Biochemistry

In cytogenetics, the two pairs of chromosomes just after they have duplicated during mitosis and before they have separated. In the tetrad, the closely aligned strands have the opportunity for ...

homochromatography

Biology; Biochemistry

A form of displacement chromatography in which unlabelled species, e.g. oligonucleotides, displace labelled ones to achieve improved separation. After electrophoresis in one dimension the initially ...

sniffer-patch

Biology; Biochemistry

A biosensor for the detection of a ion channel-activating neurotransmitter. A small area of cell membrane containing receptors for the neurotransmitter closes the end of a micropipet which acts as an ...

complementation cloning

Biology; Biochemistry

A method for identification of a DNA fragment and selection of the defective cell line upon which it confers resistance to a selective pressure, e.g. cells that are hypersensitive to ionizing ...

junk DNA

Biology; Biochemistry

DNA for which a function has yet to be identified. An elaborate nomenclature has been proposed for this DNA: any stretch of DNA is a nuon; DNA with an evolutionary potential for development of ...