10 Terms
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Molecular biology
Industry: Biology
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Molecular biology
structure-activity relationships by nuclear magnetic resonance (SAR by NMR)
Biology; Biochemistry
An approach to drug discovery. Pairs of low affinity molecules, each having an affinity constant in the micromolar range and binding to discrete areas of a biomolecule, as determined by NMR, are ...
biomolecular interaction analysis (BIA)
Biology; Biochemistry
The detection by a biosensor of a specific binding event for quantification of the ligand. One kind of BIA is surface plasmon resonance, the observation of polarization of light reflected from a ...
intasome
Biology; Biochemistry
A nucleoprotein complex active in integration of bacteriophage DNA into host DNA. Negatively supercoiled host DNA is forced to cross back over itself at points called nodes, which are sites for ...
two-component pathway
Biology; Biochemistry
A pattern of molecular organization by which responses to external stimuli are processed by cells to effect modulation of output, such as chemotaxis in bacteria, or osmolarity regulation in plant ...
mutator phenotype hypothesis
Biology; Biochemistry
A proposal for the mechanism of cancer, based the fact that mutations are relatively much more common in cancer cells than in normal cells, and even increase as a tumor grows. An initial mutation, ...
multiple-copy single-strand DNA (msDNA)
Biology; Biochemistry
A satellite DNA detected in some bacteria that features an oligoribonucleotide attached by the 2'-hydroxy group of an internal guanylate residue to the 5'-end of an oligodeoxyribonucleotide, while ...
hormone
Biology; Biochemistry
A substance that mediates interactions between non-contiguous cells; classically, a substance produced in minute amounts by an organ (an endocrine organ) in one part of the body and transported by ...
