Molecular biology

Molecular biology

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Molecular biology

two-dimensional homochromatography

Biology; Biochemistry

A form of displacement chromatography in which, after an initial separation in the first dimension of a labelled oligomer (e.g. an oligoribonucleotide), separation in the second dimension proceeds in ...

replicon

Biology; Biochemistry

A segment of the eukaryotic genome that contains several genes and is replicated as a unit from a single origin. Replication is bi-directional; its boundaries are the points where replication from ...

isoform

Biology; Biochemistry

A variant form of a protein. Isoforms may be encoded by different genes, e.g. the isoenzymes of lactate dehydrogenase, or by a single gene, the transcript of which is alternatively spliced and upon ...

propeptide

Biology; Biochemistry

The part of a protein that is proteolytically cleaved during the protein's maturation, e.g. the internal residues of proinsulin, the N-terminal residues of pepsinogen. The term is usually not used ...

ribosome-inactivating protein (RIP)

Biology; Biochemistry

One of a class of plant proteins that bind to elongation factor 2 and thus inactivate ribosomes. Type 1 (e.g. the toxin gelonin) consist of single polypeptide chain proteins; type 2 (e.g. ricin) ...

cluster of orthologous groups (COG)

Biology; Biochemistry

A collection of homologous genes that are useful for study of evolutionary relationships. A COG consists of orthologues (homologous genes that have diverged in different species from a common ...

difference Fourier method

Biology; Biochemistry

A technique of X-ray crystallography for solving the structure of a protein-ligand complex once the structure of the original protein has been deduced, by determination of the difference in ...