Genetics

Genetics

Contributors in Genetics

Genetics

The restoration of normal phenotype by gene replacement. The replaced gene can either be an intact copy of a defective gene (direct replacement), or a gene with function that can compensate for the ...

Consanguinity

Biology; Genetics

The state of genetic relatedness between two individuals who produce offspring. Consanguineous mating increases the probability of a rare recessive disease, resulting from higher probability of both ...

Copy number variation

Biology; Genetics

The most prevalent type of chromosomal structural variation, in which the number of copies of a large chromosomal or DNA segment (usually measuring thousands to millions of bases) varies between ...

Crossing-over

Biology; Genetics

The exchange of chromosome segments that occurs between homologous chromosomes during meiosis. Crossing over is the most common mechanism of recombination. The site on the chromosome where the ...

Coupling

Biology; Genetics

The presence of two specified alleles at two linked loci on the same homologous chromosome (ie, “in cis”), and the two alternative alleles on the other chromosome. For illustration, in the case of ...

Linkage disequilibrium

Biology; Genetics

The non-random association of alleles at two or more loci in a population. Linkage disequilibrium is present when the observed haplotype distribution of two or more markers in a population is ...