Molecular biology

Molecular biology

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Molecular biology

synonymous

Biology; Biochemistry

In molecular genetics, descriptive of a nucleotide substitution in a structural gene that does not result in an amino acid substitution; contrasted with non-synonymous, descriptive of base ...

two-hybrid system

Biology; Biochemistry

An assay for detecting in vivo protein-protein interactions, which depends upon expression of a reporter gene, usually in yeast. As transcription of eukaryotic enzymes are regulated by ...

The structure at the end of a eukaryotic chromosome formed by the DNA strand of the chromosome being extended by the enzyme telomerase, which is present in germ-line and cancer cells, and which adds ...

xenoduplex analysis

Biology; Biochemistry

A method of comparative gene mapping, in which PCR fragments from a species in which the gene sequence is known, forms an interspecies hybrid, a xenoduplex, with a PCR fragment from a species in ...

guide RNA (gRNA)

Biology; Biochemistry

A transcript of maxicircle or minicircle DNA, that in lower eukaryotes is thought to function in RNA editing, i.e. by the addition or deletion of U residues at specific sites in the coding regions of ...

genomic mismatch scanning (GMS)

Biology; Biochemistry

A method to detect and isolate DNA sequences that are candidate genes for inherited disorders for which the gene product is unknown, based on the absence of mismatches in DNA sequences between an ...

spectral karyotyping

Biology; Biochemistry

The color-coded display of metaphase chromosomes. Probes which are unique to each chromosome are constructed by separation of individual chromosomes and their fragmentation into 400 to 500 pieces and ...