Molecular biology

Molecular biology

Contributors in Molecular biology

Molecular biology

A quantitative measure of the strength of attachment of a moiety (the group) to the rest of the molecule; the difference in standard free energies between the group attached to the molecule and the ...

Ca2+-myristoyl switch

Biology; Biochemistry

The mechanism by which Ca 2+ signals a change in a myristoylated protein. In its non-liganded state, the acylated N-terminal amino group is buried in the protein's interior; upon binding to Ca 2+ , ...

adaptor hypothesis

Biology; Biochemistry

The proposal, made before the roles of mRNA and tRNA in protein synthesis were established, that a low-molecular-mass form of RNA provides the interface between each amino acid and the template. The ...

homomer

Biology; Biochemistry

A complex composed of only one kind of subunit; e.g. the neo-natal glycine-gated Cl - channel, which is composed of five α 2 subunits. This is contrasted with a heteromer, a complex composed of ...

hydrophobic bond

Biology; Biochemistry

The association of non-polar side chains of a protein that is driven by minimization of the relatively unfavorable interactions of water molecules with the non-polar groups, and maximization of the ...

isothermal titration calorimetry

Biology; Biochemistry

ITC; A technique for measuring binding affinities (free energy of binding) of molecules in the low millimolar to nanomolar range. The heat absorbed or released during binding under equilibrium ...

Michaelis-Menten kinetics

Biology; Biochemistry

The hyperbolic dependence of the rate of an enzymic reaction on substrate concentration that can be analyzed mathematically according to a model that requires the reaction to proceed through a ...