Molecular biology

Molecular biology

Industry: Biology

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Molecular biology

stringency

Biology; Biochemistry

During nucleic acid hybridization or reassociation, the strictness with which the Watson-Crick base-pairing is required under specified conditions of temperature, pH, salt concentration, etc. ...

The dynamic state of microtubules, the addition of subunits at one end, and their removal from the opposite end, which may account for the movement of microtubules in the cell. The nucleation site, ...

thick filament

Biology; Biochemistry

In muscle cells, an aggregate of myosin molecules in which the long, fibrous tails are intertwined in a superhelix that leaves the globular heads as knobs in a helical array over the surface. The ...

dot blotting

Biology; Biochemistry

A method to estimate the concentration of a polynucleotide or protein solution by spotting it on a sheet of nitrocellulose or nylon, hybridizing it with a radiolabelled complementary polynucleotide ...

colony hybridization

Biology; Biochemistry

A technique for screening bacterial colonies for those that contain a desired polynucleotide sequence. A plate is exposed to a labelled oligonucleotide probe with a sequence complementary to part of ...

STAT (signal transducer and activator of transcription)

Biology; Biochemistry

One of a family of proteins that mediate the actions of cytokines and growth factors. When the cytokine or growth factor receptor is occupied, a tyrosine residue of the STAT is phosphorylated and the ...

simulated annealing

Biology; Biochemistry

An energy minimization technique to refine a model structure, e.g. an X-ray crystallographic or nuclear magnetic resonance model, by simulation of heating it to a high temperature to break all ...