Molecular biology

Molecular biology

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Molecular biology

comet assay

Biology; Biochemistry

Single cell gel electrophoresis; a method for assessing DNA damage in individual cells caused, for example, by apoptosis, radiation or chemical mutation. Cells embedded in an agarose gel are ...

The technique of constructing cell lines, or transgenic animals, in which the expression of a gene may be controlled by the level of an exogenous compound. One such system, tet-on, involves a plasmid ...

gene targeting

Biology; Biochemistry

The introduction of a homologous DNA sequence into a specific site in the genome of a cell, either by replacement of the former sequence, i.e. sequence replacement, or by insertion into the former ...

forced copy-choice model

Biology; Biochemistry

One of two modes of retroviral recombination. In making a DNA transcript of the two genomic RNA strands of a retrovirus, when the polymerase encounters a break on one template strand it continues on ...

slip-and-click model

Biology; Biochemistry

A molecular explanation of the reversible coiling and uncoliling of bacterial flagella. Each flagellar protofilament is a cylindrical bundle of 11 parallel strands, which may be right-tilted (R) or ...

Nernst equation

Biology; Biochemistry

A quantitative expression of the relationship of concentration differences of an ion across a membrane: ΔΨ=(RT/nF)(ln(X n ) e /(X n ) i ), where ΔΨ is the membrane potential, R the gas constant, ...

molecular motor

Biology; Biochemistry

A complex of proteins that is responsible for energy, usually ATP hydrolysis-dependent, intracellular movement of an organelle or smaller structure along a cytoskeletal filament; e.g. the ...