Molecular biology

Molecular biology

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Molecular biology

charge relay system

Biology; Biochemistry

A tautomeric form of a protein in which a formal charge on one dissociating group is moved to another in the same protein. In serine proteinases, for example, an internal Ã- (sometimes a αγ-) ...

random activation of gene expression (RAGE)

Biology; Biochemistry

A procedure for creating a genome-wide library of cDNAs by use of several insertion vectors, each containing a promoter sequence linked to an exon and followed by an unpaired splice site. ...

The proposal that the secretory proteins are initially synthesized with an N-terminal sequence (the signal sequence or leader sequence), that assists it across the membrane of the rough endoplasmic ...

protein class

Biology; Biochemistry

A classification according to the content of α-helix and β-pleated sheet. A protein is designated <α if it has a minimum number of residues in an α-helix and fewer than a maximum in β-pleated sheets ...

protein nucleic acid (PNA)

Biology; Biochemistry

A polyamide backbone, e.g. (-NH-CH 2 -CH 2 -NR-CH 2 -CO-) n , which bears purine and pyrimidine bases (R in the formulation) and can mimic oligonucleotides by hybridizing with ssDNA or RNA. Some PNAs ...

multiplex PCR

Biology; Biochemistry

A screening technique for any of several mutations known to cluster in a relatively small number of sites (hot spots) in a gene, especially microsatellites. Simultaneous PCR reactions with several ...

radiation-induced hybrid mapping

Biology; Biochemistry

A method for location of a human genetic marker within a restricted region of a single chromosome. A hybrid cell line that contains a specific single human chromosome in each recipient rodent cell is ...