Molecular biology

Molecular biology

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Molecular biology

double-strand-break repair model

Biology; Biochemistry

double-strand-break repair model A mechanism proposed for the repair of DNA that has been fragmented at in a non-homologous region. The strands are unwound at the two ends to expose a site of ...

The concentration of 1 mole per litre; 1 mole being Avogadro's number (6.02 x 10 23 ) of molecules, which is equivalent in mass to the sum of the atomic masses (in grams) of the constituent atoms; ...

zinc finger

Biology; Biochemistry

A motif of which seven or more may appear in a DNA-binding protein. Each is characterized by two closely spaced cysteine and two histidine residues that serve as ligands for a single Zn 2+ . When ...

metal-binding finger

Biology; Biochemistry

A motif of which seven or more may appear in a DNA-binding protein. Each is characterized by two closely spaced cysteine and two histidine residues that serve as ligands for a single Zn 2+ . When ...

subtractive hybridization

Biology; Biochemistry

A variation of subtractive DNA cloning in which the restriction-nuclease-cleaved tester DNA is biotinylated before annealing with an excess of randomly sheared driver DNA. Annealing is halted at ...

biochemical genomics

Biology; Biochemistry

An experimental approach to identification of the gene responsible for a given enzymic activity. Each open reading frame (ORF) of an organism, yeast for instance, is fused to the cDNA of glutathione ...

protein truncation test (PTT)

Biology; Biochemistry

In vitro synthesized protein assay; a procedure for detection of mutations that result in a protein of significantly different size, e.g. by early termination, insertion, change in reading frame or ...