22 Terms
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Immunology
Immunology is the study of the structuree and function of the immune system which is responsible for the protection from invading foreign macromolecules or organisms. It is a broad branch of biomedical science that covers the study of all aspects of the immune system in organisms. It deals with the physiological functioning of the immune system in both healthy states and immunological disorders (autoimmune diseases, hypersensitivities, immune deficiency, transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo.
Industry: Biology
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Immunology
common variable immunodeficiency
Biology; Immunology
Common variable immunodeficiency is a relatively common deficiency in antibody production whose pathogenesis is not yet understood. There is a strong association with genes mapping within the MHC.
Wiskott–Aldrich syndrome
Biology; Immunology
The Wiskott–Aldrich syndrome is characterized by defects in the cytoskeleton of cells due to a mutation in the protein WASP. Patients with this disease are highly susceptible to pyogenic bacteria.
adoptive immunity
Biology; Immunology
Adoptive immunity is immunity conferred on a naive or irradiated recipient by transfer of lymphoid cells from an actively immunized donor. This is called adoptive transfer or adoptive immunization.
macropinocytosis
Biology; Immunology
Dendritic cells are unique in being able to carry out macropinocytosis, a process in which large amounts of extracellular fluid are taken up in single vesicles. This is one means of antigen uptake.
caseation necrosis
Biology; Immunology
Caseation necrosis is a form of necrosis seen in the center of large granulomas, such as the granulomas in tuberculosis. The term comes from the white cheesy appearance of the central necrotic area.
proto-oncogenes
Biology; Immunology
Proto-oncogenes are cellular genes that regulate growth control. When mutated or aberrantly expressed, they can contribute to the malignant transformation of cells, leading to cancer. Cf. oncogenes.
defective endogenous retroviruses
Biology; Immunology
Defective endogenous retroviruses are partial retroviral genomes integrated into host cell DNA and carried as host genes. There are a great many defective endogenous retroviruses in the mouse genome.
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22 Terms